Genotoxicity and DNA Repair: A Practical Approach (Methods in Pharmacology and Toxicology)

Genotoxicity and DNA Repair: A Practical Approach (Methods in Pharmacology and Toxicology)

L. María Sierra, Isabel Gaivão


Genotoxicity and DNA fix: a pragmatic method offers a key reference for opting for how you can study the genotoxic job of molecules or fabrics and, whilst, serves as a useful gizmo for researchers within the Environmental Mutagenesis and DNA fix fields. involved in genotoxicity assays advised by means of the “OECD guidance for the trying out of chemicals”, this quantity additionally covers different worthwhile assays, resembling a few gene mutation assays, the comet assay in several species and functions, and the clever assays of Drosophila. For all of the assays, the publication offers short theoretical introductions to the themes and up-to-date common and transformed step by step protocols to accomplish them. detailed emphasis is put on the research of nanoparticles, together with an integrative procedure research. The DNA fix part comprises a number of assays that supply info on fix task in vitro and in vivo, in addition to fresh purposes to review DNA fix in people, mobile cultures, and animal types. As a quantity within the equipment in Pharmacology and Toxicology sequence, the chapters include the type of element and key implementation suggestion that guarantees reproducible ends up in the lab.

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