The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

Jessica Wapner


A Wall highway Journal 10 top Nonfiction ebook of the Year

“Among a small cluster of first-class contemporary books on cancer.” —The ny Times

Philadelphia, 1959: A scientist scrutinizing a unmarried human mobilephone less than a microscope detects a lacking piece of DNA. That scientist, David Hungerford, had no approach of understanding that he had stumbled upon the start line of recent melanoma study— the Philadelphia chromosome. it will take medical professionals and researchers around the globe greater than 3 a long time to resolve the consequences of this landmark discovery. In 1990, the Philadelphia chromosome was once well-known because the sole explanation for a perilous blood melanoma, persistent myeloid leukemia, or CML. melanoma examine may by no means be the same.

technology journalist Jessica Wapner reconstructs greater than 40 years of an important breakthroughs, essentially explains the technology at the back of them, and will pay tribute—with broad unique reporting, together with greater than thirty-five interviews—to the handfuls of researchers, medical professionals, and sufferers with an immediate position during this inspirational tale. Their interest and backbone could eventually result in a lifesaving therapy not like whatever prior to it.

The Philadelphia Chromosome chronicles the amazing switch of fortune for the greater than 70,000 humans all over the world who're clinically determined with CML every year. it's a get together of a unprecedented triumph within the conflict opposed to melanoma and a blueprint for destiny learn, as medical professionals and scientists race to discover and deal with the genetic roots of quite a lot of cancers.

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